Cxcl17 Gene Summary [Mouse]
Predicted to enable chemokine activity. Involved in macrophage chemotaxis and positive regulation of macrophage chemotaxis. Predicted to be active in extracellular space. Is expressed in lung; male reproductive gland or organ; and small intestine. Orthologous to human CXCL17 (C-X-C motif chemokine ligand 17). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cxcl17 |
| Official Name | chemokine (C-X-C motif) ligand 17 [Source:MGI Symbol;Acc:MGI:2387642] |
| Ensembl ID | ENSMUSG00000060188 |
| Bio databases IDs | |
| Aliases | chemokine (C-X-C motif) ligand 17 |
| Synonyms | C-X-C motif chemokine ligand 17, Dcip1, DMC, RGD1304717, UNQ473, VCC-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cxcl17 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chemokine
- protein binding
- cytokine
- VEGF co-regulated chemokine 1
Pathways
Biological processes and signaling networks where the Cxcl17 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- osteoporosis
- idiopathic pulmonary fibrosis
- COVID-19
- colon adenocarcinoma
- colon epithelial cancer
- pancreatic epithelial cancer
- pancreatic ductal adenocarcinoma
- ductal pancreatic cancer
role in cell
- migration
- survival
- quantity
- number
- chemotaxis
- disruption
- invasion by
- infiltration by
- elevation in
- disruption in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cxcl17 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of monocyte chemotaxis
- angiogenesis
- macrophage chemotaxis
- negative regulation of inflammatory response
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of macrophage chemotaxis
- cell differentiation
- positive regulation vascular endothelial growth factor production
Cellular Component
Where in the cell the gene product is active
- extracellular space
Molecular Function
What the gene product does at the molecular level
- protein binding