ADCY2 Gene Summary [Human]
This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ADCY2 |
| Official Name | adenylate cyclase 2 [Source:HGNC Symbol;Acc:HGNC:233] |
| Ensembl ID | ENSG00000078295 |
| Bio databases IDs | |
| Aliases | adenylate cyclase 2 |
| Synonyms | AC2, adenylate cyclase 2, HBAC2, KIAA1060, mKIAA1060 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ADCY2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- qeha domain
- enzyme
- protein binding
- magnesium ion binding
- Adenylate cyclase, conserved domain
- C2 domain (from adenylate cyclase)
- binding protein
- cytoplasmic domain
- adenylate cyclase binding
- adenylate cyclase
- Class III nucleotidyl cyclases
- cytosolic tail domain
- Adenylyl- / guanylyl cyclase, catalytic domain
- manganese ion binding
- hydrophobic domain
Pathways
Biological processes and signaling networks where the ADCY2 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Apelin Adipocyte Signaling Pathway
- Apelin Endothelial Signaling Pathway
- Cardiac β-adrenergic Signaling
- CDK5 Signaling
- Cellular Effects of Sildenafil (Viagra)
- Corticotropin Releasing Hormone Signaling
- CXCR4 Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Dopamine Receptor Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Endocannabinoid Developing Neuron Pathway
- Endothelin-1 Signaling
- eNOS Signaling
- G Beta Gamma Signaling
- Gustation Pathway
- IL-1 Signaling
- Leptin Signaling in Obesity
- Melanocyte Development and Pigmentation Signaling
- P2Y Purinergic Receptor Signaling Pathway
- PPARα/RXRα Activation
- Protein Kinase A Signaling
- Renin-Angiotensin Signaling
- Thrombin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- myopathy
- breast cancer
- anxiety disorder
- stress related disorder
- bipolar disorder
- non-small cell lung cancer
- Huntington disease
- bipolar I disorder
- idiopathic scoliosis
- morbid obesity
role in cell
- cell cycle progression
- transformation
- response by
- doubling time
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent resistant lipid raft fraction
- Cytoplasm
- cellular membrane
- membrane rafts
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ADCY2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- cAMP biosynthetic process
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- cAMP-mediated signaling
Cellular Component
Where in the cell the gene product is active
- dendrite
- cytoplasm
- membrane raft
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- manganese ion binding
- adenylate cyclase binding
- adenylate cyclase activity