ADCY2

ADCY2 Gene Summary

This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
ADCY2
Official Name
adenylate cyclase 2 [Source:HGNC Symbol;Acc:HGNC:233]
Ensembl ID
ENSG00000078295
Bio databases IDs NCBI: 108 Ensembl: ENSG00000078295
Aliases adenylate cyclase 2
Synonyms
AC2,adenylate cyclase 2,HBAC2,KIAA1060,mKIAA1060
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • qeha domain
  • enzyme
  • protein binding
  • magnesium ion binding
  • Adenylate cyclase, conserved domain
  • C2 domain (from adenylate cyclase)
  • binding protein
  • cytoplasmic domain
  • adenylate cyclase binding
  • adenylate cyclase
  • Class III nucleotidyl cyclases
  • cytosolic tail domain
  • Adenylyl- / guanylyl cyclase, catalytic domain
  • manganese ion binding
  • hydrophobic domain

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
  • DRD4
  • ADCY1
  • F2RL1
  • ADCY5
  • forskolin
  • AKAP9
  • RNF181
  • RAF1
  • GNAI2
  • GNG2
disease
  • myopathy
  • breast cancer
  • anxiety disorder
  • stress related disorder
  • bipolar disorder
  • non-small cell lung cancer
  • Huntington disease
  • bipolar I disorder
  • idiopathic scoliosis
  • morbid obesity
regulated by
  • methylanthraniloyl-adenosine 5'-[beta,gamma-imido]-triphosphate
  • isoproterenol
  • tetradecanoylphorbol acetate
  • forskolin
  • G protein beta gamma core
  • HTT
  • mantGppNHp
  • RAF1
  • 2'-(or-3')-O-(N-methylanthraniloyl)ATP
  • GNAS
regulates
  • cyclic AMP
  • MAPK1
  • hyaluronic acid
  • G protein alpha i
  • ADCY2
  • CCND1
role in cell
  • cell cycle progression
  • transformation
  • response by
  • doubling time

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • detergent resistant lipid raft fraction
  • Cytoplasm
  • cellular membrane
  • membrane rafts
  • perikaryon
  • dendrites

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the ADCY2 gene, providing context for its role in the cell.

BIOLOGICAL PROCESS

Functions and activities the gene product is involved in
  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
  • cAMP biosynthetic process
  • adenylate cyclase-modulating G-protein coupled receptor signaling pathway
  • adenylate cyclase-activating G-protein coupled receptor signaling pathway
  • cAMP-mediated signaling

CELLULAR COMPONENT

Where in the cell the gene product is active
  • dendrite
  • cytoplasm
  • membrane raft
  • membrane
  • plasma membrane

MOLECULAR FUNCTION

What the gene product does at the molecular level
  • magnesium ion binding
  • ATP binding
  • manganese ion binding
  • adenylate cyclase binding
  • adenylate cyclase activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.