Samd4 Gene Summary [Mouse]
Predicted to enable mRNA binding activity and translation repressor activity. Predicted to be involved in nuclear-transcribed mRNA poly(A) tail shortening. Predicted to act upstream of or within positive regulation of translation. Located in synapse. Is expressed in cerebral cortex and telencephalon. Orthologous to human SAMD4A (sterile alpha motif domain containing 4A). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Samd4 |
| Official Name | sterile alpha motif domain containing 4 [Source:MGI Symbol;Acc:MGI:1921730] |
| Ensembl ID | ENSMUSG00000021838 |
| Bio databases IDs | |
| Aliases | sterile alpha motif domain containing 4 |
| Synonyms | 1700024G08RIK, 1700111L17Rik, 4933436G17RIK, Riken cDNA 4933436g17, SAMD4, SMAUG, SMAUG1, SMG, SMGA, STERILE alpha MOTIF domain containing 4, sterile alpha motif domain containing 4A, STERILE α MOTIF domain containing 4, sterile α motif domain containing 4A, sunk |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Samd4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sterile alpha motif
- translation repressor
- SAM (Sterile alpha motif )
- SAM domain (Sterile alpha motif)
- protein binding
- translation regulator
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- epithelial cancer
- lip and oral cavity carcinoma
- lip cancer
- nonobstructive azoospermia
- breast carcinoma
role in cell
- development
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- postsynaptic density (PSD) fractions
- glutaminergic synapse
- fibrillar center
- cell junction
- Nucleus
- granules
- cytosol
- synaptosomes
- synapse
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Samd4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of translation
- negative regulation of translation
- nuclear-transcribed mRNA poly(A) tail shortening
Cellular Component
Where in the cell the gene product is active
- dendrite
- cell junction
- cytoplasmic mRNA processing body
- cytosol
- synapse
- fibrillar center
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- translation repressor activity
- mRNA binding