Arf4 Gene Summary [Mouse]
Predicted to enable several functions, including GTP binding activity; NAD+-protein-arginine ADP-ribosyltransferase activity; and epidermal growth factor receptor binding activity. Involved in regulation of postsynapse organization. Acts upstream of or within several processes, including apical protein localization; dendritic spine development; and establishment or maintenance of epithelial cell apical/basal polarity. Located in Golgi apparatus and plasma membrane. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; extraembryonic component; nervous system; nose; and skeleton. Orthologous to human ARF4 (ARF GTPase 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arf4 |
| Official Name | ADP-ribosylation factor 4 [Source:MGI Symbol;Acc:MGI:99433] |
| Ensembl ID | ENSMUSG00000021877 |
| Bio databases IDs | |
| Aliases | ADP-ribosylation factor 4 |
| Synonyms | ARF2, ARF GTPase 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arf4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- epidermal growth factor receptor binding
- Ras family
- GTPase
- enzyme
- protein binding
- phospholipase activator
- GTP binding
- Sar1p-like members of the Ras-family of small GTPases
- ADP-ribosylation factor family
- pentosyltransferase
- guanyl-nucleotide exchange factor
- Ras of Complex, Roc, domain of DAPkinase
- ADP-ribosylation factor
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Arf4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- organismal death
- tremor
- papillary thyroid carcinoma
- papillary thyroid cancer
role in cell
- accumulation in
- apoptosis
- expression in
- migration
- invasion by
- transepithelial electrical resistance
- assembly
- development
- organization
- tubulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- glutaminergic synapse
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- cytosol
- membrane ruffles
- Golgi membrane
- dendritic spines
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arf4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- retrograde vesicle-mediated transport, Golgi to ER
- intracellular protein transport
- learning
- positive regulation of transcription from RNA polymerase II promoter
- dendritic spine development
- ER to Golgi vesicle-mediated transport
- vesicle-mediated transport
- negative regulation of apoptotic process
- establishment or maintenance of epithelial cell apical/basal polarity
- apical protein localization
- regulation of reactive oxygen species metabolic process
- cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- membrane
- dendritic spine
- cytosol
- ruffle membrane
- Golgi membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- guanyl-nucleotide exchange factor activity
- epidermal growth factor receptor binding