Slc39a14 Gene Summary [Mouse]
Enables monoatomic anion:monoatomic cation symporter activity and transition metal ion transmembrane transporter activity. Involved in several processes, including cellular response to glucose stimulus; intracellular zinc ion homeostasis; and transition metal ion transport. Acts upstream of or within iron ion transport and zinc ion transport. Located in basolateral plasma membrane. Is expressed in several structures, including autopod; dentate gyrus subgranular zone; ear; liver; and skeleton. Human ortholog(s) of this gene implicated in hypermanganesemia with dystonia 2. Orthologous to human SLC39A14 (solute carrier family 39 member 14). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc39a14 |
| Official Name | solute carrier family 39 (zinc transporter), member 14 [Source:MGI Symbol;Acc:MGI:2384851] |
| Ensembl ID | ENSMUSG00000022094 |
| Bio databases IDs | |
| Aliases | solute carrier family 39 (zinc transporter), member 14 |
| Synonyms | BC021530, cig19, FAD-123, HCIN, HMNDYT2, KIAA0062, LOC213048, LZT-Hs4, NET34, solute carrier family 39 member 14, solute carrier family 39 (zinc transporter), member 14, ZIP14 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc39a14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ferrous iron transporter
- manganese ion transporter
- ZIP Zinc transporter
- solute:cation symporter
- cadmium ion transporter
- iron ion transporter
- anion:cation symporter
- protein binding
- zinc ion transporter
- bicarbonate transporter
- transporter
Pathways
Biological processes and signaling networks where the Slc39a14 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- hereditary disorder
- hyperostosis cranialis interna
- hypermanganesemia with dystonia type 2
- epileptic seizure
- growth failure
- torticollis
- hepatic steatosis
- colorectal cancer
- colorectal carcinoma
role in cell
- apoptosis
- binding in
- phosphorylation in
- expression in
- proliferation
- differentiation
- ricin resistance
- response by
- uptake in
- gluconeogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- Mitochondria
- apical membrane
- basolateral membrane
- lysosome membrane
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc39a14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- manganese ion homeostasis
- gluconeogenesis
- insulin receptor signaling pathway
- cellular zinc ion homeostasis
- chondrocyte differentiation
- positive regulation of G-protein coupled receptor protein signaling pathway
- regulation of hormone levels
- cellular response to insulin stimulus
- negative regulation of cyclic-nucleotide phosphodiesterase activity
- cellular response to glucose stimulus
- cadmium ion transmembrane transport
- manganese ion transmembrane transport
- zinc ion import
- iron assimilation
- zinc ion transmembrane transport
- cellular cation homeostasis
- bicarbonate transport
- iron ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- late endosome membrane
- membrane
- basolateral plasma membrane
- plasma membrane
- lysosomal membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- iron ion transmembrane transporter activity
- anion:cation symporter activity
- cadmium ion transmembrane transporter activity
- zinc ion transmembrane transporter activity
- manganese ion transmembrane transporter activity
- ferrous iron transmembrane transporter activity