Fyb Gene Summary [Mouse]
The protein encoded by this gene is an adapter molecule that affects T cell receptor signaling and contains multiple protein-protein interaction domains. It is thought to couple T cell receptor stimulation with activation of integrin function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
Details
| Type | Protein Coding |
| Official Symbol | Fyb |
| Official Name | FYN binding protein [Source:MGI Symbol;Acc:MGI:1346327] |
| Ensembl ID | ENSMUSG00000022148 |
| Bio databases IDs | |
| Aliases | FYN binding protein |
| Synonyms | ADAP, B630013F22RIK, FYB, FYB-120/130, FYN-binding, FYN binding protein 1, p120/130, p120/p130, PRO0823, RGD1563421, SLAP-130, THC3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fyb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glutamic acid-lysine rich domain
- binding protein
- protein binding
- receptor binding
- proline rich domain
- Helically-extended SH3 domain
- tyrosine phosphorylation site
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the Fyb gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- chronic pain
- Waldenström macroglobulinemia
- peripheral arterial disease
- acute kidney injury
- thrombocytopenia
- vascular dementia
- thrombocytopenia type 3
- autosomal dominant polycystic kidney disease
- laser induced choroidal neovascularization
role in cell
- expression in
- proliferation
- quantity
- morphology
- fragmentation
- activation in
- phosphorylation in
- binding in
- number
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- peripheral membrane fraction
- membrane fraction
- intracellular compartment
- Cytoplasm
- intracellular space
- actin cytoskeleton
- Plasma Membrane
- cytosol
- perinuclear space
- phagosomes
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fyb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- integrin-mediated signaling pathway
- immune response
- protein localization in plasma membrane
- T cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- anchoring junction
- actin cytoskeleton
- cytosol
- macromolecular complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- lipid binding
- receptor binding