Llgl2 Gene Summary [Mouse]
Predicted to enable GTPase activator activity; PDZ domain binding activity; and myosin II binding activity. Acts upstream of or within establishment or maintenance of polarity of embryonic epithelium; labyrinthine layer development; and post-embryonic development. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be active in cortical actin cytoskeleton and plasma membrane. Is expressed in several structures, including cardiovascular system; endocrine gland; genitourinary system; gut; and nasal cavity epithelium. Orthologous to human LLGL2 (LLGL scribble cell polarity complex component 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Llgl2 |
| Official Name | LLGL2 scribble cell polarity complex component [Source:MGI Symbol;Acc:MGI:1918843] |
| Ensembl ID | ENSMUSG00000020782 |
| Bio databases IDs | |
| Aliases | LLGL2 scribble cell polarity complex component |
| Synonyms | 9130006H11Rik, HGL, Hugl-2, LGL2, LLGL2 scribble cell polarity complex component, LLGLH2, LLGL scribble cell polarity complex component 2, MLGL, RGD1560307 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Llgl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PKC phosphorylation site
- WD40
- protein binding
- PDZ-domain binding
- LLGL2
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- expression in
- G1 phase
- methylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cell cortex
- Plasma Membrane
- Golgi Apparatus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Llgl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cortical actin cytoskeleton organization
- cell division
- regulation of establishment or maintenance of cell polarity
- regulation of Notch signaling pathway
- establishment or maintenance of epithelial cell apical/basal polarity
- Golgi to plasma membrane transport
- establishment of spindle orientation
- exocytosis
- leucine transport
Cellular Component
Where in the cell the gene product is active
- adherens junction
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- cortical actin cytoskeleton
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activator activity
- myosin II binding
- PDZ domain binding