Mtss1 Gene Summary [Mouse]
Enables actin filament binding activity and identical protein binding activity. Involved in several processes, including cellular response to fluid shear stress; glomerulus morphogenesis; and renal tubule development. Acts upstream of or within several processes, including actin filament polymerization; adherens junction maintenance; and positive regulation of actin filament bundle assembly. Located in adherens junction and cytoplasm. Is expressed in several structures, including central nervous system; metanephros; myotome; sensory organ; and spleen. Used to study non-Hodgkin lymphoma. Orthologous to human MTSS1 (MTSS I-BAR domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mtss1 |
| Official Name | MTSS I-BAR domain containing 1 [Source:MGI Symbol;Acc:MGI:2384818] |
| Ensembl ID | ENSMUSG00000022353 |
| Bio databases IDs | |
| Aliases | MTSS I-BAR domain containing 1 |
| Synonyms | 2310003N14Rik, D130001D01Rik, HIP13, KIAA0429, MIM, MIMA, MIMB, mKIAA0429, MTSS I-BAR domain containing 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mtss1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- activation domain
- coiled-coil domain
- protein binding
- receptor binding
- Bin/Amphiphysin/Rvs domain
- identical protein binding
- inverse-Bin-Amphiphysins-Rvs domain
- proline rich domain
- WH2 motif
- phosphorylation site
- actin filament binding
- WH2
- actin monomer binding
- actin binding
- IRSp53/MIM homology domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
- coronary artery disease
- irritable bowel syndrome
- fibrosis
- glomerulosclerosis
- polyuria
- ataxia
- chronic periodontal disease
role in cell
- migration
- degradation in
- apoptosis
- proliferation
- differentiation
- formation
- cell viability
- quantity
- organization
- chemotaxis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- actin cytoskeleton
- Plasma Membrane
- centrosome
- actin bundles
- cytosol
- plasma membrane projections
- endocytotic vesicle
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mtss1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- renal tubule morphogenesis
- transmembrane receptor protein tyrosine kinase signaling pathway
- cell adhesion
- nephron tubule epithelial cell differentiation
- plasma membrane organization
- cellular response to fluid shear stress
- glomerulus morphogenesis
- negative regulation of epithelial cell proliferation
- adherens junction maintenance
- microspike assembly
- positive regulation of actin filament bundle assembly
- epithelial cell proliferation involved in renal tubule morphogenesis
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- endocytic vesicle
- cytoplasm
- ruffle
- actin cytoskeleton
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- actin binding
- phospholipid binding
- receptor binding
- actin monomer binding