Ppp1r3a Gene Summary [Mouse]
Predicted to enable glycogen binding activity; protein phosphatase 1 binding activity; and protein serine/threonine phosphatase activity. Predicted to be involved in regulation of glycogen biosynthetic process. Predicted to act upstream of or within glycogen metabolic process. Predicted to be located in membrane. Predicted to be part of protein phosphatase type 1 complex. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in hypoglycemia and type 2 diabetes mellitus. Orthologous to human PPP1R3A (protein phosphatase 1 regulatory subunit 3A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppp1r3a |
| Official Name | protein phosphatase 1, regulatory subunit 3A [Source:MGI Symbol;Acc:MGI:2153588] |
| Ensembl ID | ENSMUSG00000042717 |
| Bio databases IDs | |
| Aliases | protein phosphatase 1, regulatory subunit 3A |
| Synonyms | GM, G-subunit of PHOSPHATASE 1, INACTIVE PHOSPHATASE FC, PP1beta.GM, PP1G, PP1 G subunit, PPP1R3, protein phosphatase 1 regulatory subunit 3A, protein phosphatase 1, regulatory subunit 3A, RG1, RGD1561312, RGL |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ppp1r3a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Starch/carbohydrate-binding module (family 53)
- Carbohydrate/starch-binding module (family 21)
- protein serine/threonine phosphatase
- phosphoprotein phosphatase
- phosphatase
- PBD_PPP1R3
Pathways
Biological processes and signaling networks where the Ppp1r3a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insomnia
- obesity
- weight gain
- insulin resistance
- Huntington disease
- susceptibility to insulin resistance
- non-small cell lung cancer
- digenic insulin resistance
- digenic type II diabetes mellitus
- severe insulin resistance with obesity
role in cell
- proliferation
- differentiation
- dephosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ppp1r3a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycogen metabolic process
- regulation of glycogen biosynthetic process
Cellular Component
Where in the cell the gene product is active
- protein phosphatase type 1 complex
- membrane
Molecular Function
What the gene product does at the molecular level
- protein phosphatase 1 binding
- glycogen binding