Jmy Gene Summary [Mouse]
Enables transcription coactivator activity. Involved in actin nucleation; actin polymerization-dependent cell motility; and positive regulation of apoptotic process. Acts upstream of or within intrinsic apoptotic signaling pathway by p53 class mediator and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in skeletal muscle. Orthologous to human JMY (junction mediating and regulatory protein, p53 cofactor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Jmy |
| Official Name | junction-mediating and regulatory protein [Source:MGI Symbol;Acc:MGI:1913096] |
| Ensembl ID | ENSMUSG00000021690 |
| Bio databases IDs | |
| Aliases | junction-mediating and regulatory protein |
| Synonyms | AA591059, junction-mediating and regulatory protein, junction mediating and regulatory protein, p53 cofactor, LOC683593, WHAMM2, WHDC1L3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Jmy often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- transcription regulator
- p300/cbp binding domain
- transcription co-activator
- nuclear localization sequence
- central domain
- protein binding
- N-terminal of Junction-mediating and WASP homolog-associated
- acidic domain
- polyproline motif
- proline rich domain
- Junction-mediating and -regulatory protein
Pathways
Biological processes and signaling networks where the Jmy gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- organismal death
- androgenic alopecia
- COVID-19
- rotator cuff injury
- hearing loss
role in cell
- proliferation
- quantity
- expression in
- apoptosis
- survival
- upregulation in
- response
- formation
- enlargement
- permeability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- autophagic vacuoles
- cytoplasmic vesicles
- cell membrane leading edge
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Jmy gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- positive regulation of transcription, DNA-dependent
- signal transduction by p53 class mediator resulting in induction of apoptosis
- positive regulation of apoptotic process
- Arp2/3 complex-mediated actin nucleation
- actin polymerization-dependent cell motility
- cellular response to starvation
- 'de novo' actin filament nucleation
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoskeleton
- cell leading edge
- cytoplasm
- cytoplasmic vesicle
- endomembrane system
- autophagic vacuole membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding
- transcription coactivator activity
- microtubule binding
- Arp2/3 complex binding