Traf5 Gene Summary [Mouse]
Predicted to enable enzyme binding activity; identical protein binding activity; and signaling adaptor activity. Involved in interleukin-17-mediated signaling pathway and regulation of gene expression. Acts upstream of or within positive regulation of cell population proliferation and signal transduction. Located in cytoplasmic side of plasma membrane. Part of CD40 receptor complex. Is expressed in genitourinary system and tongue muscle. Orthologous to human TRAF5 (TNF receptor associated factor 5). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Traf5 |
| Official Name | TNF receptor-associated factor 5 [Source:MGI Symbol;Acc:MGI:107548] |
| Ensembl ID | ENSMUSG00000026637 |
| Bio databases IDs | |
| Aliases | TNF receptor-associated factor 5 |
| Synonyms | AC175315.1, MGC:39780, RNF84, TNF receptor-associated factor 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Traf5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- MATH
- ubiquitin protein ligase activity
- enzyme binding
- coiled-coil domain
- TRAF domain
- isoleucine zipper domain
- protein binding
- zinc binding domain
- identical protein binding
- TRAF-type zinc finger
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- transporter
- Zinc finger, C3HC4 type (RING finger)
Pathways
Biological processes and signaling networks where the Traf5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- April Mediated Signaling
- B Cell Activating Factor Signaling
- CD27 Signaling in Lymphocytes
- CD40 Signaling
- IL-17 Signaling
- Lymphotoxin β Receptor Signaling
- NF-κB Signaling
- OX40 Signaling Pathway
- RANK Signaling in Osteoclasts
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Small Cell Lung Cancer Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- cleft lip
- glioma
- glioma formation
- experimental intestinal endometriosis
- plasma cell myeloma
- uveitis
- Sjogren syndrome keratoconjunctivitis sicca
role in cell
- activation
- production in
- proliferation
- phosphorylation in
- expression in
- development
- apoptosis
- cell death
- activation in
- necrosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- perinuclear region
- Plasma Membrane
- centrosome
- cytosol
- cytoplasmic face of plasma membrane
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Traf5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- positive regulation of cell proliferation
- signal transduction involved in regulation of gene expression
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- regulation of I-kappaB kinase/NF-kappaB cascade
- regulation of apoptotic process
- positive regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of NF-kappaB transcription factor activity
- tumor necrosis factor-mediated signaling pathway
- apoptotic process
- mRNA stabilization
- protein K63-linked ubiquitination
Cellular Component
Where in the cell the gene product is active
- centrosome
- cytoplasm
- cytosol
- CD40 receptor complex
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- zinc ion binding
- ubiquitin protein ligase binding
- protein binding
- tumor necrosis factor receptor binding
- thioesterase binding