Mep1a Gene Summary [Mouse]
Predicted to enable metallodipeptidase activity and metalloendopeptidase activity. Acts upstream of or within epidermal growth factor receptor signaling pathway. Located in membrane. Is expressed in several structures, including gut and metanephros. Orthologous to human MEP1A (meprin A subunit alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mep1a |
| Official Name | meprin 1 alpha [Source:MGI Symbol;Acc:MGI:96963] |
| Ensembl ID | ENSMUSG00000023914 |
| Bio databases IDs | |
| Aliases | meprin 1 alpha |
| Synonyms | AI098089, LOC688307, Mep-1, meprin 1 alpha, meprin 1 α, Meprin alpha, Meprin a subunit alpha, Meprin a subunit α, Meprin a, α, Meprin α, PPHA |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mep1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- metallopeptidase
- ZnMc
- Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
- MATH
- metalloexopeptidase
- dipeptidase
- peptidase
- Astacin (Peptidase family M12A)
- Zinc-dependent metalloprotease
- protein binding
- MAM domain, meprin/A5/mu
- EGF_CA
Pathways
Biological processes and signaling networks where the Mep1a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colon cancer
- diabetes mellitus
- chronic allograft nephropathy
- colitis
- organismal death
- liver cancer
- hepatoblastoma
role in cell
- cell death
- molecular cleavage in
- loss
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Extracellular Space
- cellular membrane
- apical membrane
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mep1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epidermal growth factor receptor ligand maturation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- plasma membrane
- meprin A complex
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- metallodipeptidase activity
- metalloendopeptidase activity
- metallopeptidase activity