Zfp521 Gene Summary [Mouse]
Predicted to enable protein domain specific binding activity. Acts upstream of or within neuron fate commitment. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including bone; branchial arch; central nervous system; embryo mesenchyme; and genitourinary system. Used to study schizophrenia. Orthologous to human ZNF521 (zinc finger protein 521). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zfp521 |
| Official Name | zinc finger protein 521 [Source:MGI Symbol;Acc:MGI:95459] |
| Ensembl ID | ENSMUSG00000024420 |
| Bio databases IDs | |
| Aliases | zinc finger protein 521 |
| Synonyms | B930086A16Rik, EHZF, Evi3, LIP3, Zfp521, zinc finger protein 521 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zfp521 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Zinc-finger double domain
- protein domain specific binding
- protein binding
- zinc finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- growth failure
- Wilms tumor
- Wilms tumorigenesis
- osteopenia
- attention deficit hyperactivity disorder
- androgenic alopecia
- insomnia
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- myeloproliferative disorder
role in cell
- proliferation
- expression in
- migration
- quantity
- binding in
- growth
- number
- differentiation
- activity
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zfp521 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron fate commitment
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription