Apba1 Gene Summary [Mouse]
Predicted to enable several functions, including PDZ domain binding activity; amyloid-beta binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in presynaptic modulation of chemical synaptic transmission. Acts upstream of or within several processes, including carboxylic acid transport; in utero embryonic development; and locomotory behavior. Located in membrane. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and presynaptic active zone membrane. Is expressed in central nervous system and dorsal root ganglion. Orthologous to human APBA1 (amyloid beta precursor protein binding family A member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Apba1 |
| Official Name | amyloid beta (A4) precursor protein binding, family A, member 1 [Source:MGI Symbol;Acc:MGI:1860297] |
| Ensembl ID | ENSMUSG00000024897 |
| Bio databases IDs | |
| Aliases | amyloid beta (A4) precursor protein binding, family A, member 1 |
| Synonyms | 6430513E09RIK, amyloid beta precursor protein binding family A member 1, AMYLOID precursor protein-binding family A, amyloid β precursor protein binding family A member 1, D9S411E, LIN10, Mint, MINT1, Urop11, X11, X11A, X11ALPHA |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Apba1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- munc-18 binding domain
- protein kinase binding
- canonical PDZ domain
- protein binding
- phosphotyrosine binding domain
- Pleckstrin homology-like domain
- beta-amyloid binding
- PDZ domain
- Stxbp1 binding domain
- PDZ-domain binding
- binding protein
- CASK binding domain
- phosphatidylinositol-4,5-bisphosphate binding
- cpPDZ_Deg_HtrA-like
- PDZ binding motif
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- ataxia
- Alzheimer disease
- idiopathic scoliosis
- Waldenström macroglobulinemia
- tinnitus
role in cell
- migration
- expression in
- morphology
- activity
- accumulation in
- adhesion
- endocytosis by
- transmission
- binding in
- paired-pulse facilitation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- glutaminergic synapse
- intracellular compartment
- intracellular space
- perinuclear region
- cellular membrane
- Plasma Membrane
- vesicles
- Golgi Apparatus
- cytosol
- presynaptic membrane
- trans face of the Golgi apparatus
- dendritic spines
- synaptic vesicles
- synaptosomes
- synapse
- perikaryon
- axons
- dendrites
- dendritic shafts
- detergent-soluble fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Apba1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- glutamate secretion
- macromolecular complex assembly
- axon cargo transport
- nervous system development
- gamma-aminobutyric acid secretion
- synaptic transmission
- cell adhesion
- intracellular protein transport
- locomotory behavior
- in utero embryonic development
- regulation of gene expression
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- synaptic vesicle
- dendritic spine
- cytosol
- Golgi apparatus
- presynaptic active zone membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- beta-amyloid binding