Nucks1 Gene Summary [Mouse]
Predicted to enable several functions, including DNA binding activity; chromatin binding activity; and transcription coactivator activity. Involved in several processes, including intracellular glucose homeostasis; positive regulation of transcription by RNA polymerase II; and regulation of insulin receptor signaling pathway. Acts upstream of or within glucose homeostasis and positive regulation of insulin receptor signaling pathway. Located in chromatin; cytoplasm; and nucleus. Is expressed in central nervous system; embryo; liver; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human NUCKS1 (nuclear casein kinase and cyclin dependent kinase substrate 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nucks1 |
| Official Name | nuclear casein kinase and cyclin-dependent kinase substrate 1 [Source:MGI Symbol;Acc:MGI:1934811] |
| Ensembl ID | ENSMUSG00000026434 |
| Bio databases IDs | |
| Aliases | nuclear casein kinase and cyclin-dependent kinase substrate 1 |
| Synonyms | 2700010L10Rik, 8430423A01Rik, HMG LIKE protein P1, JC7, LOC100130123, LOC100366178, NUCKS, nuclear casein kinase and cyclin-dependent kinase substrate 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nucks1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- single-stranded DNA binding
- double-stranded DNA binding
- transcription factor binding
- chromatin binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- neoplasia
- insulin resistance
- Parkinson disease
- peptic ulcer disease
- kidney stones
- weight gain
- atrial fibrillation
- hepatic steatosis
- osteosarcoma
role in cell
- proliferation
- expression in
- migration
- phosphorylation in
- binding in
- formation
- G1/S phase transition
- S phase
- organization
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- nucleoli
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nucks1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation by host of viral transcription
- positive regulation of insulin receptor signaling pathway
- regulation of DNA strand elongation
- double-strand break repair via homologous recombination
- regulation of DNA replication
- regulation of insulin receptor signaling pathway
- chromatin organization
- positive regulation of transcription from RNA polymerase II promoter
- cellular response to X-ray
- cellular glucose homeostasis
- gene conversion
- replication fork processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nucleolus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- transcription coactivator activity
- double-stranded DNA binding
- chromatin binding
- single-stranded DNA binding