Mcm10 Gene Summary [Mouse]
Enables enzyme binding activity. Acts upstream of or within cell population proliferation. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in nuclear replication fork. Is expressed in several structures, including adrenal gland; brain; gonad; gut; and immune system. Human ortholog(s) of this gene implicated in immunodeficiency 80. Orthologous to human MCM10 (minichromosome maintenance 10 replication initiation factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mcm10 |
| Official Name | minichromosome maintenance 10 replication initiation factor [Source:MGI Symbol;Acc:MGI:1917274] |
| Ensembl ID | ENSMUSG00000026669 |
| Bio databases IDs | |
| Aliases | minichromosome maintenance 10 replication initiation factor |
| Synonyms | 2410041F14Rik, C330019M07Rik, CNA43, DNA43, IMD80, minichromosome maintenance 10 replication initiation factor, PRO2249 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mcm10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mcm10 replication factor
- enzyme binding
- Primase zinc finger
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- lung adenocarcinoma
- lung adenocarcinoma formation
- immunodeficiency 80 with congenital cardiomyopathy
- organismal death
- cervical cancer
- colorectal cancer
- fetal restrictive cardiomyopathy with lymphoreticular hypoplasia
- colon carcinoma
- colon epithelial cancer
role in cell
- apoptosis
- cell viability
- expression in
- cell death
- S phase
- proliferation
- DNA damage response
- G2/M phase
- accumulation
- shortening
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- soluble fraction
- chromatin fraction
- detergent-insoluble fractions
- insoluble fractions
- Cytoplasm
- nuclear foci
- nucleoplasm
- nucleoli
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mcm10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- DNA-dependent DNA replication initiation
- response to DNA damage stimulus
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear replication fork
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA replication origin binding
- identical protein binding
- protein binding
- metal ion binding
- enzyme binding
- single-stranded DNA binding