Apbb1ip Gene Summary [Mouse]
Acts upstream of or within T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell and positive regulation of cell adhesion. Located in cytosol and plasma membrane. Part of T cell receptor complex. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system; liver; and molar. Orthologous to human APBB1IP (amyloid beta precursor protein binding family B member 1 interacting protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Apbb1ip |
| Official Name | amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein [Source:MGI Symbol;Acc:MGI:1861354] |
| Ensembl ID | ENSMUSG00000026786 |
| Bio databases IDs | |
| Aliases | amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein |
| Synonyms | 9930118P07RIK, amyloid beta precursor protein binding family B member 1 interacting protein, amyloid β precursor protein binding family B member 1 interacting protein, INAG1, PREL1, Prp48, RARP1, RIAM |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Apbb1ip often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ubl1_cv_Nsp3_N-like
- PH domain
- protein binding
- Pleckstrin homology-like domain
- proline rich domain
Pathways
Biological processes and signaling networks where the Apbb1ip gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colitis
- Ullrich congenital muscular dystrophy
role in cell
- activation in
- adhesion
- number
- development
- replication in
- reorganization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- cytosol
- filopodia
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Apbb1ip gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
- positive regulation of cell adhesion
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- focal adhesion
- cytosol
- T cell receptor complex
- plasma membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein binding