Lamc3 Gene Summary [Mouse]
Acts upstream of or within several processes, including glial cell differentiation; retina development in camera-type eye; and visual perception. Located in basement membrane. Is expressed in several structures, including central nervous system; eye; lower jaw molar epithelium; oral region gland; and submandibular gland primordium. Orthologous to human LAMC3 (laminin subunit gamma 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lamc3 |
| Official Name | laminin gamma 3 [Source:MGI Symbol;Acc:MGI:1344394] |
| Ensembl ID | ENSMUSG00000026840 |
| Bio databases IDs | |
| Aliases | laminin gamma 3 |
| Synonyms | 1110064A23Rik, Lamc3 (predicted), Laminin gamma3, laminin subunit gamma 3, laminin subunit γ 3, Laminin γ 3, LOC102554659, OCCM |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lamc3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Crescentin protein
- laminin domain VI
- Laminin N-terminal (Domain VI)
- laminin domain V
- Laminin B (Domain IV)
- Calcium binding and coiled-coil domain (CALCOCO1) like
- Tumor necrosis factor receptor superfamily (TNFRSF)
- EGF_CA
- Laminin Domain I
- Laminin-type epidermal growth factor-like domai
- structural molecule
- Apolipoprotein A1/A4/E domain
- Laminin EGF domain
Pathways
Biological processes and signaling networks where the Lamc3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- occipital cortical malformations
- hereditary disorder
- aldosterone producing adrenocortical adenoma
- adenoma formation
- conotruncal heart malformations
- estrogen receptor positive breast cancer
- oral cancer
- human papilloma virus infection
- male pattern hair loss
- complex neurodevelopmental disorder
role in cell
- expression in
- quantity
- growth
- adhesion
- development
- deposition in
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- apical ectoplasmic specialization
- intracellular space
- apical compartment
- basal compartment
- cellular membrane
- photoreceptor inner segments
- extracellular matrix
- perikaryon
- interphotoreceptor matrix
- basement membrane
- apical processes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lamc3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- astrocyte development
- retina development in camera-type eye
- cell morphogenesis
- cell adhesion
- visual perception
Cellular Component
Where in the cell the gene product is active
- basement membrane
- membrane
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- structural molecule activity