Il1f5 Gene Summary [Mouse]
Predicted to enable cytokine activity and interleukin-1 receptor binding activity. Acts upstream of or within negative regulation of interleukin-6 production. Predicted to be located in cytoplasm. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in pustular psoriasis 14. Orthologous to human IL36RN (interleukin 36 receptor antagonist). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il1f5 |
| Official Name | interleukin 1 family, member 5 (delta) [Source:MGI Symbol;Acc:MGI:1859325] |
| Ensembl ID | ENSMUSG00000026983 |
| Bio databases IDs | |
| Aliases | interleukin 1 family, member 5 (delta) |
| Synonyms | FIL1, FIL1D, Fil1delta, FIL1(DELTA), Fil1 δ, FIL1(δ), If36rn, IL1D, IL1 delta, IL1F5, Il-1h3, IL1HY1, IL1L1, IL1RP3, IL1 δ, IL-36Ra, interleukin 36 receptor antagonist, PSORP, PSORS14 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Il1f5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- interleukin-1 receptor antagonist
- protein binding
- cytokine
- beta-trefoil domain found in the interleukin-1 (IL-1) family of cytokines
Pathways
Biological processes and signaling networks where the Il1f5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- acute myeloid leukemia
- B cell cancer
- pustular psoriasis 14
- hyperkeratosis
- generalized pustular psoriasis
- autoinflammatory disorder
- acanthosis
- psoriasis
- plasma cell neoplasm
role in cell
- apoptosis
- growth
- production in
- quantity
- number
- activation
- frequency
- infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Il1f5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cytokine-mediated signaling pathway
- negative regulation of interleukin-6 production
- inflammatory response to antigenic stimulus
- cellular response to lipopolysaccharide
- signal transduction
- innate immune response
- negative regulation of interleukin-17 production
- negative regulation of interferon-gamma production
- antifungal humoral response
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- interleukin-1 receptor antagonist activity
- cytokine activity
- interleukin-1 receptor binding