IL36RN Gene Summary [Human]
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | IL36RN |
| Official Name | interleukin 36 receptor antagonist [Source:HGNC Symbol;Acc:HGNC:15561] |
| Ensembl ID | ENSG00000136695 |
| Bio databases IDs | |
| Aliases | interleukin 36 receptor antagonist, family of interleukin 1-delta, interleukin-1 receptor antagonist homolog 1, interleukin-1 HY1, IL-1 related protein 3 |
| Synonyms | FIL1, FIL1D, Fil1delta, FIL1(DELTA), Fil1 δ, FIL1(δ), If36rn, IL1D, IL1 delta, IL1F5, Il-1h3, IL1HY1, IL1L1, IL1RP3, IL1 δ, IL-36Ra, interleukin 36 receptor antagonist, PSORP, PSORS14 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IL36RN often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- interleukin-1 receptor antagonist
- protein binding
- cytokine
- beta-trefoil domain found in the interleukin-1 (IL-1) family of cytokines
Pathways
Biological processes and signaling networks where the IL36RN gene in human plays a role, providing insight into its function and relevance in health or disease.
- Acute Phase Response Signaling
- Agranulocyte Adhesion and Diapedesis
- Atherosclerosis Signaling
- Cholecystokinin/Gastrin-mediated Signaling
- Communication between Innate and Adaptive Immune Cells
- Dendritic Cell Maturation
- FXR/RXR Activation
- Graft-versus-Host Disease Signaling
- Granulocyte Adhesion and Diapedesis
- Hepatic Cholestasis
- IL-10 Signaling
- IL-6 Signaling
- LPS/IL-1 Mediated Inhibition of RXR Function
- LXR/RXR Activation
- NF-κB Signaling
- p38 MAPK Signaling
- PPAR Signaling
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Systemic Lupus Erythematosus Signaling
- Toll-like Receptor Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- acute myeloid leukemia
- B cell cancer
- pustular psoriasis 14
- hyperkeratosis
- generalized pustular psoriasis
- autoinflammatory disorder
- acanthosis
- psoriasis
- plasma cell neoplasm
role in cell
- apoptosis
- growth
- production in
- quantity
- number
- activation
- frequency
- infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IL36RN gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cytokine-mediated signaling pathway
- negative regulation of interleukin-6 production
- inflammatory response to antigenic stimulus
- cellular response to lipopolysaccharide
- signal transduction
- innate immune response
- negative regulation of interleukin-17 production
- negative regulation of interferon-gamma production
- antifungal humoral response
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- interleukin-1 receptor antagonist activity
- cytokine activity
- interleukin-1 receptor binding