Bub3 Gene Summary [Mouse]
This gene encodes a component of the mitotic spindle assembly complex. The encoded protein is involved in the regulation of chromosome segregation during oocyte meiosis. Disruption of this gene results in the accumulation of mitotic errors and is lethal in the embryonic stage. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
Details
| Type | Protein Coding |
| Official Symbol | Bub3 |
| Official Name | BUB3 mitotic checkpoint protein [Source:MGI Symbol;Acc:MGI:1343463] |
| Ensembl ID | ENSMUSG00000066979 |
| Bio databases IDs | |
| Aliases | BUB3 mitotic checkpoint protein |
| Synonyms | Aa2-050, BUB3L, BUB3 mitotic checkpoint protein, hBUB3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bub3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- polycystic ovary syndrome
- tumorigenesis
- weight loss
- cachexia
- cataract disease
- lymphomagenesis
- hematologic cancer
- lymphoid cancer
role in cell
- proliferation
- apoptosis
- quantity
- processing in
- morphology
- survival
- damage in
- checkpoint control
- missegregation
- aneuploidy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- microtubules
- cytosol
- nucleoplasm
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bub3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle spindle assembly checkpoint
- cell division
- meiotic cell cycle
- attachment of spindle microtubules to kinetochore
- protein localization to kinetochore
Cellular Component
Where in the cell the gene product is active
- cytosol
- mitotic checkpoint complex
- kinetochore
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin binding