Pkia Gene Summary [Mouse]
Enables cAMP-dependent protein kinase inhibitor activity and protein kinase A catalytic subunit binding activity. Acts upstream of or within negative regulation of macromolecule metabolic process; negative regulation of protein import into nucleus; and regulation of G2/M transition of mitotic cell cycle. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human PKIA (cAMP-dependent protein kinase inhibitor alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pkia |
| Official Name | protein kinase inhibitor, alpha [Source:MGI Symbol;Acc:MGI:104747] |
| Ensembl ID | ENSMUSG00000027499 |
| Bio databases IDs | |
| Aliases | protein kinase inhibitor, alpha |
| Synonyms | cAMP-dependent protein kinase inhibitor alpha, cAMP-dependent protein kinase inhibitor α, PKIALPHA, Pki α, PRKACN1, protein kinase inhibitor, alpha, protein kinase inhibitor, α |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pkia often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase A binding
- nuclear export signal
- protein kinase binding
- cAMP-dependent protein kinase inhibitor
- cAMP-dependent protein kinase inhibitor activity
- protein binding
Pathways
Biological processes and signaling networks where the Pkia gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pulmonary hypertensive arterial disease
- uterine leiomyoma
- leiomyomatosis
- endometriosis
- morbid obesity
- brain cancer
- Huntington disease
role in cell
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pkia gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of cAMP-dependent protein kinase activity
- negative regulation of protein import into nucleus
- regulation of G2/M transition of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein kinase A catalytic subunit binding
- cAMP-dependent protein kinase inhibitor activity