PKIA Gene Summary [Human]
The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. This protein was demonstrated to interact with and inhibit the activities of both C alpha and C beta catalytic subunits of the PKA. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PKIA |
| Official Name | cAMP-dependent protein kinase inhibitor alpha [Source:HGNC Symbol;Acc:HGNC:9017] |
| Ensembl ID | ENSG00000171033 |
| Bio databases IDs | |
| Aliases | cAMP-dependent protein kinase inhibitor alpha |
| Synonyms | cAMP-dependent protein kinase inhibitor alpha, cAMP-dependent protein kinase inhibitor α, PKIALPHA, Pki α, PRKACN1, protein kinase inhibitor, alpha, protein kinase inhibitor, α |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PKIA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase A binding
- nuclear export signal
- protein kinase binding
- cAMP-dependent protein kinase inhibitor
- cAMP-dependent protein kinase inhibitor activity
- protein binding
Pathways
Biological processes and signaling networks where the PKIA gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pulmonary hypertensive arterial disease
- uterine leiomyoma
- leiomyomatosis
- endometriosis
- morbid obesity
- brain cancer
- Huntington disease
role in cell
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PKIA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of cAMP-dependent protein kinase activity
- negative regulation of protein import into nucleus
- regulation of G2/M transition of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein kinase A catalytic subunit binding
- cAMP-dependent protein kinase inhibitor activity