Rnpc3 Gene Summary [Mouse]

Predicted to enable U12 snRNA binding activity and pre-mRNA intronic binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in nucleoplasm. Predicted to be part of U12-type spliceosomal complex. Is expressed in central nervous system; dorsal root ganglion; nose; trigeminal nerve; and urinary system. Human ortholog(s) of this gene implicated in combined or isolated pituitary growth hormone deficiency 7. Orthologous to human RNPC3 (RNA binding region (RNP1, RRM) containing 3). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Rnpc3
Official Name
RNA-binding region (RNP1, RRM) containing 3 [Source:MGI Symbol;Acc:MGI:1914475]
Ensembl ID
ENSMUSG00000027981
Bio databases IDs NCBI: 67225 Ensembl: ENSMUSG00000027981
Aliases RNA-binding region (RNP1, RRM) containing 3
Synonyms 2810441O16RIK, AI447568, C030014B17Rik, CPHD7, FLJ25070, IGHD5, LOC686263, RBM40, RNA-binding region (RNP1, RRM) containing 3, RNP, SNRNP65
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rnpc3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • RNA recognition motif (RRM) superfamily
  • RNA recognition motif

Pathways

Biological processes and signaling networks where the Rnpc3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
  • poly rI:rC-RNA
  • FADD
  • CST5
  • DAP3
  • pexidartinib
disease
  • isolated growth hormone deficiency type V
  • combined or isolated pituitary hormone deficiency type 7
  • HER2 negative hormone receptor negative breast cancer

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • spliceosomes
  • nucleoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Rnpc3 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • RNA splicing
  • nuclear mRNA splicing, via spliceosome

Cellular Component

Where in the cell the gene product is active
  • U12-type spliceosomal complex
  • nucleus
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • pre-mRNA intronic binding
  • U12 snRNA binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.