Ubap1 Gene Summary [Mouse]
Predicted to enable ubiquitin binding activity. Predicted to be involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Predicted to be located in cytosol; intracellular membrane-bounded organelle; and plasma membrane. Predicted to be part of ESCRT I complex. Used to study hereditary spastic paraplegia 80. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 80. Orthologous to human UBAP1 (ubiquitin associated protein 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ubap1 |
| Official Name | ubiquitin-associated protein 1 [Source:MGI Symbol;Acc:MGI:2149543] |
| Ensembl ID | ENSMUSG00000028437 |
| Bio databases IDs | |
| Aliases | ubiquitin-associated protein 1 |
| Synonyms | 2700092A01Rik, NAG20, SPG80, UAP, UBAP, ubiquitin-associated protein 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ubap1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- ubiquitin binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Plasma Membrane
- cytosol
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ubap1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
- membrane fission
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- intracellular membrane-bounded organelle
- ESCRT I complex
- cytosol
- endosome membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin binding