Sema3c Gene Summary [Rat]
Predicted to enable chemorepellent activity; neuropilin binding activity; and semaphorin receptor binding activity. Predicted to be involved in several processes, including chordate embryonic development; circulatory system development; and mesenchymal cell differentiation. Predicted to act upstream of or within several processes, including blood vessel remodeling; dichotomous subdivision of terminal units involved in salivary gland branching; and heart development. Predicted to be active in extracellular space and plasma membrane. Orthologous to human SEMA3C (semaphorin 3C). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sema3c |
| Official Name | semaphorin 3C [Source:RGD Symbol;Acc:1309343] |
| Ensembl ID | ENSRNOG00000006526 |
| Bio databases IDs | |
| Aliases | semaphorin 3C |
| Synonyms | 1110036B02Rik, sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C, SEMAE, semaphorin 3C, Semaphorin E, SemE |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sema3c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- semaphorin domain
- Plexin repeat
- semaphorin receptor binding
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- Sema domain
- The Sema domain, a protein interacting module, of semaphorins and plexins
Pathways
Biological processes and signaling networks where the Sema3c gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoarthritis
- pancreatic ductal adenocarcinoma
- hypothyroidism
- Langerhans cell histiocytosis
- chronic obstructive pulmonary disease
- pervasive developmental disorder
- pancreatic epithelial cancer
- ductal pancreatic cancer
- serous ovarian adenocarcinoma
- serous ovarian cancer
role in cell
- expression in
- phosphorylation in
- growth
- cell viability
- apoptosis
- proliferation
- migration
- influx
- colony formation by
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sema3c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neural tube development
- negative chemotaxis
- limb bud formation
- post-embryonic development
- axon guidance
- pulmonary myocardium development
- response to xenobiotic stimulus
- dichotomous subdivision of terminal units involved in salivary gland branching
- outflow tract septum morphogenesis
- cardiac right ventricle morphogenesis
- blood vessel remodeling
- immune response
- neural crest cell migration
- somitogenesis
- semaphorin-plexin signaling pathway
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- chemorepellent activity
- semaphorin receptor binding