Pon3 Gene Summary [Mouse]
Predicted to enable carboxylic ester hydrolase activity and protein homodimerization activity. Involved in negative regulation of superoxide anion generation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyotrophic lateral sclerosis; and atherosclerosis. Orthologous to human PON3 (paraoxonase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Pon3 |
| Official Name | paraoxonase 3 [Source:MGI Symbol;Acc:MGI:106686] |
| Ensembl ID | ENSMUSG00000029759 |
| Bio databases IDs | |
| Aliases | paraoxonase 3 |
| Synonyms | 2810004E20, paraoxonase 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pon3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- strictosidine synthase
- dihydrocoumarin hydrolase
- protein homodimerization
- enzyme
- arylesterase
- lactonohydrolase
Pathways
Biological processes and signaling networks where the Pon3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- atherosclerosis
- obesity
- liver cancer
- aortic valve calcification
- nonalcoholic steatohepatitis
- hepatitis B virus-related hepatocellular carcinoma
- weight gain
- jaundice
- adenoid cystic carcinoma
role in cell
- apoptosis
- size
- respiration in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- Nucleus
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- Golgi membrane
- mitochondria-associated membranes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pon3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carboxylic acid catabolic process
- negative regulation of superoxide anion generation
- renal sodium ion transport
- regulation of cellular response to drug
- establishment of localization in cell
- response to toxin
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- extracellular space
- extracellular vesicular exosome
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- metal ion binding
- aryldialkylphosphatase activity
- arylesterase activity