Ptprh Gene Summary [Mouse]
Predicted to enable cadherin binding activity and protein tyrosine phosphatase activity. Involved in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity. Located in microvillus. Is expressed in intestine; stomach; and testis. Orthologous to human PTPRH (protein tyrosine phosphatase receptor type H). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Ptprh |
| Official Name | protein tyrosine phosphatase, receptor type, H [Source:MGI Symbol;Acc:MGI:3026877] |
| Ensembl ID | ENSMUSG00000035429 |
| Bio databases IDs | |
| Aliases | protein tyrosine phosphatase, receptor type, H |
| Synonyms | BEM2, Protein tyrosine phosphatase h, protein tyrosine phosphatase receptor type H, protein tyrosine phosphatase, receptor type, H, Ptp-bem2, R-PTP-H, SAP1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ptprh often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein-tyrosine-phoshatase
- Protein tyrosine phosphatase, catalytic domain
- PTP_DSP_cys
- protein binding
- Fibronectin type 3 domain
- Protein tyrosine phosphatase, catalytic domain motif
- PTPase domain
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- docking domain
- Protein-tyrosine phosphatase
- transmembrane receptor protein tyrosine phosphatase
- FN3
- transmembrane domain
- phosphatase
- intracellular domain
- cadherin binding
Pathways
Biological processes and signaling networks where the Ptprh gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- small cell lung cancer
- non-small cell lung cancer
role in cell
- phosphorylation in
- migration
- cell death
- dephosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cytosol
- nuclear speckles
- microvilli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ptprh gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein dephosphorylation
- apoptotic process
Cellular Component
Where in the cell the gene product is active
- microvillus membrane
- nuclear speck
- cytosol
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein tyrosine phosphatase activity
- cadherin binding
- transmembrane receptor protein tyrosine phosphatase activity