Gstp2 Gene Summary [Mouse]
Enables glutathione transferase activity. Acts upstream of or within glutathione metabolic process. Located in cytosol. Is expressed in several structures, including alimentary system; cranium; eye; heart; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including allergic disease (multiple); carcinoma (multiple); hematologic cancer (multiple); reproductive organ cancer (multiple); and respiratory system disease (multiple). Orthologous to human GSTP1 (glutathione S-transferase pi 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gstp2 |
| Official Name | glutathione S-transferase, pi 2 [Source:MGI Symbol;Acc:MGI:95864] |
| Ensembl ID | ENSMUSG00000038155 |
| Bio databases IDs | |
| Aliases | glutathione S-transferase, pi 2 |
| Synonyms | AC175315.3, Glutathione s-transferase, chain b, glutathione S-transferase, pi 1, glutathione S-transferase, pi 2, glutathione S-transferase, pi, pseudogene, Gm37208, Gm3934, Gst-3, GSTP, Gstp2, GSTPi, GSTpiA, GstpiB, Gstp-ps, Lysyl Oxidase 2 |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gstp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glutathione S-transferase, C-terminal domain
- Glutathione S-transferase, N-terminal domain
- C-terminal, alpha helical domain of the Glutathione S-transferase family
- protein kinase binding
- fatty acid binding
- kinase regulator
- JUN kinase binding
- enzyme
- binding protein
- glutathione transferase
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- glutathione peroxidase
- toxin binding
Pathways
Biological processes and signaling networks where the Gstp2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- tumorigenesis
- liver cancer
- epithelial cancer
- cholangiocarcinoma cancer
- cancer
- myocardial necrosis
- epithelial neoplasia
- papillomatosis
- benign neoplasia
role in cell
- expression in
- apoptosis
- cell viability
- proliferation
- quantity
- cell death
- phosphorylation in
- glycolysis in
- endocytosis in
- response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- Mitochondria
- cytosol