Bpgm Gene Summary [Mouse]
Enables bisphosphoglycerate mutase activity. Involved in glycolytic process. Acts upstream of or within several processes, including defense response to protozoan; erythrocyte development; and oxygen transport. Is expressed in several structures, including alimentary system; cerebral cortex; liver; oocyte; and respiratory system. Human ortholog(s) of this gene implicated in familial erythrocytosis 8. Orthologous to human BPGM (bisphosphoglycerate mutase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bpgm |
| Official Name | 2,3-bisphosphoglycerate mutase [Source:MGI Symbol;Acc:MGI:1098242] |
| Ensembl ID | ENSMUSG00000038871 |
| Bio databases IDs | |
| Aliases | 2,3-bisphosphoglycerate mutase |
| Synonyms | 2,3-Bisphosphoglycerate Mutase, Ab2-098, bisphosphoglycerate mutase, DPGM, ECYT8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bpgm often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Histidine phosphatase superfamily (branch 1)
- Phosphoglycerate mutase family
- bisphosphoglycerate phosphatase
- phosphoglycerate mutase
- phosphatase
- bisphosphoglycerate mutase
- protein binding
- Histidine phosphatase domain
Pathways
Biological processes and signaling networks where the Bpgm gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- renal cell carcinoma
- hepatocellular carcinoma
- bisphosphoglycerate mutase deficiency
- liver cancer
- metabolic syndrome X
- renal cell cancer
regulates
- oxygen
- nucleoside 5'-phosphate
role in cell
- development
- response by
- glycolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Nucleus
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bpgm gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- oxygen transport
- glycolysis
- establishment of blood-brain barrier
- erythrocyte development
- respiratory gaseous exchange
- defense response to protozoan
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- bisphosphoglycerate mutase activity
- 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity
- hydrolase activity