Azi2 Gene Summary [Mouse]
Involved in negative regulation of canonical NF-kappaB signal transduction. Acts upstream of or within several processes, including T cell activation; dendritic cell differentiation; and dendritic cell proliferation. Located in cytoplasm. Is expressed in central nervous system and retina. Orthologous to human AZI2 (5-azacytidine induced 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Azi2 |
| Official Name | 5-azacytidine induced gene 2 [Source:MGI Symbol;Acc:MGI:1351332] |
| Ensembl ID | ENSMUSG00000039285 |
| Bio databases IDs | |
| Aliases | 5-azacytidine induced gene 2 |
| Synonyms | 5-azacytidine induced 2, 5-azacytidine induced gene 2, AZ2, NAP1, TBKBP2, TILP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Azi2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TBK1/IKKi-binding domain
- TBD domain
- Ciliary protein causing Leber congenital amaurosis disease
- protein binding
Pathways
Biological processes and signaling networks where the Azi2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neonatal late-onset sepsis
- osteoporosis
role in cell
- expression in
- activation
- production in
- apoptosis
- differentiation
- binding in
- activation in
- inhibition in
- function
- generation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Azi2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- dendritic cell differentiation
- T cell activation
- defense response to virus
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- dendritic cell proliferation
- mitotic cell cycle
- type I interferon-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding