AZI2 Gene Summary [Human]
AZI2, or NAP1, contributes to the activation of NFKB (see MIM 164011)-dependent gene expression by activating IKK-related kinases, such as NAK (TBK1; MIM 604834) (Fujita et al., 2003 [PubMed 14560022]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | AZI2 |
| Official Name | 5-azacytidine induced 2 [Source:HGNC Symbol;Acc:HGNC:24002] |
| Ensembl ID | ENSG00000163512 |
| Bio databases IDs | |
| Aliases | 5-azacytidine induced 2 |
| Synonyms | 5-azacytidine induced 2, 5-azacytidine induced gene 2, AZ2, NAP1, TBKBP2, TILP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AZI2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TBK1/IKKi-binding domain
- TBD domain
- Ciliary protein causing Leber congenital amaurosis disease
- protein binding
Pathways
Biological processes and signaling networks where the AZI2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neonatal late-onset sepsis
- osteoporosis
role in cell
- expression in
- activation
- production in
- apoptosis
- differentiation
- binding in
- activation in
- inhibition in
- function
- generation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AZI2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- dendritic cell differentiation
- T cell activation
- defense response to virus
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- dendritic cell proliferation
- mitotic cell cycle
- type I interferon-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding