Kazn Gene Summary [Mouse]
Predicted to be involved in keratinization. Predicted to be located in several cellular components, including cornified envelope; desmosome; and nuclear speck. Is expressed in several structures, including blastocyst; early embryo; embryo ectoderm; extraembryonic component; and genitourinary system. Orthologous to human KAZN (kazrin, periplakin interacting protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kazn |
| Official Name | kazrin, periplakin interacting protein [Source:MGI Symbol;Acc:MGI:1918779] |
| Ensembl ID | ENSMUSG00000040606 |
| Bio databases IDs | |
| Aliases | kazrin, periplakin interacting protein |
| Synonyms | 2310007B04Rik, 9030409G11Rik, C1orf196, FLJ43806, KAZ, Kazrin, kazrin, periplakin interacting protein, KIAA1026, RP1-21O18.1, THC2323059, W84167 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kazn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sterile alpha motif
- TPR/MLP1/MLP2-like protein
- Autophagy protein 16 (ATG16)
- Chromatin assembly factor 1 complex p150 subunit, N-terminal
- Tropomyosin like
- Ezrin/radixin/moesin, alpha-helical domain
- SAM (Sterile alpha motif )
- Transforming acidic coiled-coil-containing protein (TACC), C-terminal
- SAM domain (Sterile alpha motif)
- Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
- protein binding
- Domain of unknown function (DUF4200)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- plasma cell myeloma
- liver cancer
- epithelial cancer
- inflammatory bowel disease
- Crohn disease
- ulcerative colitis
- Alzheimer disease
- septic shock
- nonalcoholic steatohepatitis
- schizophrenia
role in cell
- cell viability
- apoptosis
- differentiation
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cornified envelope
- cell borders
- actin cytoskeleton
- Nucleus
- microtubules
- desmosomes
- cell-cell contacts
- cytosol
- apical membrane
- nucleoplasm
- nuclear speckles
- microvilli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kazn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- keratinization
Cellular Component
Where in the cell the gene product is active
- cornified envelope
- cytoskeleton
- nuclear speck
- cytosol
- desmosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding