Cables1 Gene Summary [Mouse]
Acts upstream of or within nervous system development. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Is expressed in several structures, including central nervous system; genitourinary system; liver; retina; and vibrissa. Orthologous to human CABLES1 (Cdk5 and Abl enzyme substrate 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cables1 |
| Official Name | CDK5 and Abl enzyme substrate 1 [Source:MGI Symbol;Acc:MGI:1927065] |
| Ensembl ID | ENSMUSG00000040957 |
| Bio databases IDs | |
| Aliases | CDK5 and Abl enzyme substrate 1 |
| Synonyms | CABL1, CABLES, CDK5 and Abl enzyme substrate 1, HsT2563, IK3-1, LOC91768 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cables1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cyclin box
- Cyclin box fold superfamily
- protein binding
- Sh3 domain binding motif
Pathways
Biological processes and signaling networks where the Cables1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- neoplasia
- obesity
- cancer
- epithelial cancer
- lung adenocarcinoma
- gastroesophageal reflux
- breast carcinoma
- non-insulin-dependent diabetes mellitus
- epithelial uterine cancer
role in cell
- apoptosis
- cell death
- proliferation
- binding in
- growth
- cell cycle progression
- colony formation
- outgrowth
- G1/S phase transition
- stabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- growth cone
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cables1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- nervous system development
- regulation of cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding