Otud1 Gene Summary [Mouse]
Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in protein K63-linked deubiquitination. Is expressed in embryo. Orthologous to human OTUD1 (OTU deubiquitinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Otud1 |
| Official Name | OTU domain containing 1 [Source:MGI Symbol;Acc:MGI:1918448] |
| Ensembl ID | ENSMUSG00000043415 |
| Bio databases IDs | |
| Aliases | OTU domain containing 1 |
| Synonyms | 4933428L19Rik, DUBA7, OTDC1, OTU deubiquitinase 1, OTU domain containing 1, RGD1563344 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Otud1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptidase
- ubiquitin-specific protease
- ETGE motif
- protein binding
- OTU-like cysteine protease
- OTU (ovarian tumor) domain family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- periodontitis
- experimental periodontitis
- weight loss
- alveolar bone loss
- perivascular fibrosis
- non-insulin-dependent diabetes mellitus
- infection by HIV-1
role in cell
- expression in
- binding in
- growth
- phosphorylation in
- formation
- cellular infiltration by
- formation in
- recruitment
- ubiquitination in
- deubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Otud1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- protein K63-linked deubiquitination
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity