Adcy8 Gene Summary [Mouse]
Enables calcium- and calmodulin-responsive adenylate cyclase activity. Involved in several processes, including cellular response to glucagon stimulus; cellular response to morphine; and regulation of synaptic plasticity. Acts upstream of or within long-term memory. Located in several cellular components, including basolateral plasma membrane; neuronal cell body membrane; and postsynaptic density. Is active in several cellular components, including Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; and presynaptic membrane. Is expressed in several structures, including alimentary system; nephrogenic zone; nervous system; respiratory system; and sensory organ. Orthologous to human ADCY8 (adenylate cyclase 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adcy8 |
| Official Name | adenylate cyclase 8 [Source:MGI Symbol;Acc:MGI:1341110] |
| Ensembl ID | ENSMUSG00000022376 |
| Bio databases IDs | |
| Aliases | adenylate cyclase 8 |
| Synonyms | AC8, ADCY3, adenylate cyclase 8, HBAC1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Adcy8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein dimerization
- calmodulin binding
- protein phosphatase binding
- enzyme
- protein binding
- Adenylate cyclase, conserved domain
- adenylate cyclase
- actin binding
- IQ domain
- calcium/calmodulin-responsive adenylate cyclase
- protein homodimerization
- Class III nucleotidyl cyclases
- Adenylyl- / guanylyl cyclase, catalytic domain
- protein heterodimerization
- phosphatase binding
Pathways
Biological processes and signaling networks where the Adcy8 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Apelin Adipocyte Signaling Pathway
- Apelin Endothelial Signaling Pathway
- Cardiac β-adrenergic Signaling
- CDK5 Signaling
- Cellular Effects of Sildenafil (Viagra)
- Corticotropin Releasing Hormone Signaling
- CXCR4 Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Dopamine Receptor Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Endocannabinoid Developing Neuron Pathway
- Endothelin-1 Signaling
- eNOS Signaling
- Gustation Pathway
- IL-1 Signaling
- Leptin Signaling in Obesity
- Melanocyte Development and Pigmentation Signaling
- P2Y Purinergic Receptor Signaling Pathway
- PPARα/RXRα Activation
- Protein Kinase A Signaling
- Renin-Angiotensin Signaling
- Synaptic Long Term Potentiation
- Thrombin Signaling
- α-Adrenergic Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- Alzheimer disease
- prostate cancer
- Duchenne muscular dystrophy
- breast carcinoma
- chronic kidney disease
- post-traumatic stress disorder
- memory deficits
regulates
- cyclic AMP
- Ca2+
- CREB
- insulin
- enzyme
- D-glucose
- corticosterone
- ADCY8
role in cell
- response
- long-term potentiation
- response by
- long-term potentiation in
- elevation in
- synaptic depression in
- depotentiation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cellular membrane
- actin cytoskeleton
- caveolar membranes
- apical membrane
- presynaptic membrane
- caveolae
- basolateral membrane
- sperm tail
- neurites
- synapse
- membrane rafts
- clathrin-coated pits
- perikaryon
- axons
- dendrites
- postsynaptic density
- excitatory synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Adcy8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of long-term synaptic potentiation
- activation of protein kinase A activity
- positive regulation of long term synaptic depression
- regulation of cellular response to stress
- memory
- learning or memory
- regulation of insulin secretion
- locomotory behavior
- cellular response to calcium ion
- cellular response to glucagon stimulus
- cellular response to glucose stimulus
- positive regulation of synaptic plasticity
- cellular response to morphine
- glucose mediated signaling pathway
- positive regulation of insulin secretion involved in cellular response to glucose stimulus
- intracellular signal transduction
- opioid receptor signaling pathway
- cAMP biosynthetic process
- signal transduction
- protein homooligomerization
- cytosolic calcium ion homeostasis
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- elevation of cytosolic calcium ion concentration
- long-term memory
- glucose homeostasis
- positive regulation of CREB transcription factor activity
- protein oligomerization
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- postsynaptic density
- excitatory synapse
- neuronal cell body membrane
- plasma membrane
- dendrite
- caveola
- presynaptic active zone
- coated pit
- membrane
- membrane raft
- actin cytoskeleton
- basolateral plasma membrane
- axon
- apical plasma membrane
- clathrin coated vesicle membrane
Molecular Function
What the gene product does at the molecular level
- calcium- and calmodulin-responsive adenylate cyclase activity
- ATP binding
- calmodulin binding
- protein homodimerization activity
- actin binding
- protein heterodimerization activity
- metal ion binding
- protein dimerization activity
- protein phosphatase 2A binding
- adenylate cyclase activity