Hs3st1 Gene Summary [Mouse]
Enables [heparan sulfate]-glucosamine 3-sulfotransferase activity. Involved in glycosaminoglycan biosynthetic process and heparan sulfate proteoglycan biosynthetic process. Is active in Golgi apparatus. Is expressed in several structures, including appendicular skeleton; ear; exocrine system; hindlimb; and nervous system. Orthologous to human HS3ST1 (heparan sulfate-glucosamine 3-sulfotransferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hs3st1 |
| Official Name | heparan sulfate (glucosamine) 3-O-sulfotransferase 1 [Source:MGI Symbol;Acc:MGI:1201606] |
| Ensembl ID | ENSMUSG00000051022 |
| Bio databases IDs | |
| Aliases | heparan sulfate (glucosamine) 3-O-sulfotransferase 1 |
| Synonyms | 3OST, 3-Ost-1, 3OST-I, D5Wsu110e, HEPARAN SULFATE D-GLUCOSAMINYL 3-O-SULFOTRANSFERASE 1 precursor, heparan sulfate (glucosamine) 3-O-sulfotransferase 1, heparan sulfate-glucosamine 3-sulfotransferase 1, HEPARAN sulphATE D-GLUCOSAMINYL 3-O-sulphOTRANSFERASE 1 precursor, heparan sulphate (glucosamine) 3-O-sulphotransferase 1, heparan sulphate-glucosamine 3-sulphotransferase 1, Hsg3ost |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hs3st1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sulfotransferase
- [heparan sulfate]-glucosamine 3-sulfotransferase 1
- Sulfotransferase domain
- enzyme
- Sulfotransferase family
Pathways
Biological processes and signaling networks where the Hs3st1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- intrauterine growth retardation
- angioimmunoblastic T-cell lymphoma
- infection by Adeno-associated virus 9
regulates
- heparan sulfate proteoglycan
- SERPINC1
- glycosaminoglycan
role in cell
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi lumen
- Golgi Apparatus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hs3st1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heparan sulfate proteoglycan biosynthetic process, enzymatic modification
- glycosaminoglycan biosynthetic process
Cellular Component
Where in the cell the gene product is active
- Golgi lumen
Molecular Function
What the gene product does at the molecular level
- [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity
- sulfotransferase activity