Slit3 Gene Summary [Mouse]
Predicted to enable Roundabout binding activity and heparin binding activity. Involved in aortic valve morphogenesis; atrioventricular valve morphogenesis; and ventricular septum morphogenesis. Acts upstream of or within several processes, including axon guidance; negative regulation of cell population proliferation; and negative regulation of gene expression. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; heart; limb; and sensory organ. Used to study congenital diaphragmatic hernia. Orthologous to human SLIT3 (slit guidance ligand 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slit3 |
| Official Name | slit guidance ligand 3 [Source:MGI Symbol;Acc:MGI:1315202] |
| Ensembl ID | ENSMUSG00000056427 |
| Bio databases IDs | |
| Aliases | slit guidance ligand 3 |
| Synonyms | b2b2362.1Clo, MEGF5, SLIL2, SLIT1, slit2, slit guidance ligand 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slit3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Leucine-rich repeats, outliers
- Leucine-rich repeats, typical (most populated) subfamily
- Glycoprotein hormone beta chain homologues
- LamG
- Human growth factor-like EGF
- Leucine rich repeat
- Leucine rich repeat C-terminal domain
- BspA type Leucine rich repeat region (6 copies)
- receptor binding
- Leucine Rich repeats (2 copies)
- EGF_CA
- Concanavalin A-like lectin/glucanases superfamily
- EGF domain
- Leucine rich repeat N-terminal domain
- laminin G domain
Pathways
Biological processes and signaling networks where the Slit3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hallux valgus
- squamous cell cancer
- peritoneal endometriosis
- colorectal cancer
- androgenic alopecia
- Huntington disease
- multiple sclerosis
- lymphomagenesis
- endometrial adenocarcinoma
- endometrial adenocarcinoma formation
role in cell
- expression in
- proliferation
- migration
- growth
- cell death
- activity
- differentiation
- formation
- development
- guidance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Nucleus
- Plasma Membrane
- granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slit3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Roundabout signaling pathway
- apoptotic process involved in luteolysis
- negative chemotaxis
- chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration
- aortic valve morphogenesis
- atrioventricular valve morphogenesis
- negative regulation of cell proliferation
- axon guidance
- ventricular septum morphogenesis
- axon extension involved in axon guidance
- negative regulation of gene expression
- negative regulation of chemokine-mediated signaling pathway
- negative regulation of cell growth
- cellular response to hormone stimulus
- response to cortisol stimulus
Cellular Component
Where in the cell the gene product is active
- extracellular space
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- Roundabout binding
- calcium ion binding
- heparin binding