Fgf18 Gene Summary [Mouse]
Predicted to enable growth factor activity; type 1 fibroblast growth factor receptor binding activity; and type 2 fibroblast growth factor receptor binding activity. Acts upstream of or within several processes, including positive regulation of chondrocyte differentiation; positive regulation of signal transduction; and skeletal system development. Predicted to be located in nucleolus. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; musculoskeletal system; and sensory organ. Orthologous to human FGF18 (fibroblast growth factor 18). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fgf18 |
| Official Name | fibroblast growth factor 18 [Source:MGI Symbol;Acc:MGI:1277980] |
| Ensembl ID | ENSMUSG00000057967 |
| Bio databases IDs | |
| Aliases | fibroblast growth factor 18 |
| Synonyms | D130055P09RIK, Fgf6a, fibroblast growth factor 18, ZFGF5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fgf18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-trefoil_FGF
- type 2 fibroblast growth factor receptor binding
- type 1 fibroblast growth factor receptor binding
- fibroblast growth factor receptor binding
- growth factor
Pathways
Biological processes and signaling networks where the Fgf18 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- osteoarthritis
- androgenic alopecia
- non-small cell lung cancer
- sleep apnea syndrome
- hip or knee osteoarthritis
- backache
- serous ovarian adenocarcinoma
- serous ovarian cancer
role in cell
- expression in
- proliferation
- quantity
- migration
- growth
- survival
- colony formation
- differentiation
- cisplatin sensitivity
- G1 phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- Nucleus
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fgf18 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of MAP kinase activity
- cell proliferation
- positive regulation of cell proliferation
- fibroblast growth factor receptor signaling pathway
- chondrocyte development
- anatomical structure morphogenesis
- positive regulation of angiogenesis
- angiogenesis
- positive regulation of vascular endothelial growth factor receptor signaling pathway
- lung development
- signal transduction
- cell-cell signaling
- positive regulation of MAPK cascade
- positive regulation of blood vessel endothelial cell migration
- organ morphogenesis
- ERK1 and ERK2 cascade
- vascular endothelial growth factor receptor signaling pathway
- positive regulation of gene expression
- positive regulation of protein phosphorylation
- positive regulation of ERK1 and ERK2 cascade
- intramembranous ossification
- cell differentiation
- regulation of endothelial cell proliferation
- endochondral ossification
- positive regulation of chondrocyte differentiation
- positive regulation of endothelial cell chemotaxis to fibroblast growth factor
- regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- extracellular region
- nucleolus
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- type 2 fibroblast growth factor receptor binding
- type 1 fibroblast growth factor receptor binding