Gmfg Gene Summary [Mouse]
Predicted to enable Arp2/3 complex binding activity. Acts upstream of or within actin filament debranching and negative regulation of Arp2/3 complex-mediated actin nucleation. Predicted to be active in cortical actin cytoskeleton. Is expressed in several structures, including brain; cardiovascular system; gut; hemolymphoid system; and yolk sac. Orthologous to human GMFG (glia maturation factor gamma). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gmfg |
| Official Name | glia maturation factor, gamma [Source:MGI Symbol;Acc:MGI:1927135] |
| Ensembl ID | ENSMUSG00000060791 |
| Bio databases IDs | |
| Aliases | glia maturation factor, gamma |
| Synonyms | 0610039G16Rik, 2310057N07Rik, glia maturation factor gamma, glia maturation factor, gamma, glia maturation factor γ, glia maturation factor, γ, GMF-GAMMA, GMF-γ |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gmfg often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cofilin/tropomyosin-type actin-binding protein
- Actin depolymerization factor/cofilin- and gelsolin-like domains
- binding protein
- protein kinase inhibitor activity
- enzyme activator activity
- growth factor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- dyslexia
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
role in cell
- activation in
- expression in
- cell viability
- migration
- invasion
- adhesion
- degradation in
- organization
- function
- debranching
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gmfg gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- actin filament debranching
- protein phosphorylation
- negative regulation of Arp2/3 complex-mediated actin nucleation
Cellular Component
Where in the cell the gene product is active
- secretory granule lumen
- extracellular region
- cortical actin cytoskeleton
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- actin binding
- enzyme activator activity
- protein kinase inhibitor activity
- Arp2/3 complex binding