Prcp Gene Summary [Mouse]
Enables metallocarboxypeptidase activity. Involved in angiotensin maturation. Acts upstream of or within several processes, including angiogenesis involved in wound healing; plasma kallikrein-kinin cascade; and regulation of thyroid hormone receptor signaling pathway. Located in basal part of cell and lysosome. Is active in extracellular region. Is expressed in several structures, including axial musculature; brain meninges; craniocervical region bone; foregut; and liver lobe. Orthologous to human PRCP (prolylcarboxypeptidase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Prcp |
| Official Name | prolylcarboxypeptidase (angiotensinase C) [Source:MGI Symbol;Acc:MGI:1919711] |
| Ensembl ID | ENSMUSG00000061119 |
| Bio databases IDs | |
| Aliases | prolylcarboxypeptidase (angiotensinase C) |
| Synonyms | 2510048K03RIK, 2610104A14Rik, angiotensinase C, HUMPCP, PCP, PROLYLCARBOXYPEPTIDASE, prolylcarboxypeptidase (angiotensinase C) |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prcp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alpha/beta hydrolases
- serine-type carboxypeptidase
- peptidase
- metallocarboxypeptidase
- Serine carboxypeptidase S28
- lysosomal Pro-X carboxypeptidase
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- idiopathic scoliosis
- thrombosis
- tinnitus
- coronary artery disease
- metabolic syndrome X
role in cell
- production in
- proliferation
- cell viability
- activation in
- growth
- degradation in
- survival
- migration by
- inactivation in
- cellular infiltration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Extracellular Space
- basal compartment
- cellular membrane
- Plasma Membrane
- lysosome
- secretory granule membrane
- lysosome membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prcp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- angiogenesis involved in wound healing
- proteolysis
- glucose homeostasis
- regulation of reactive oxygen species metabolic process
- energy homeostasis
- negative regulation of systemic arterial blood pressure
- plasma kallikrein-kinin cascade
- regulation of thyroid hormone mediated signaling pathway
- regulation of blood vessel endothelial cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- basal part of cell
- intracellular membrane-bounded organelle
- azurophil granule membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- serine-type carboxypeptidase activity
- dipeptidyl-peptidase activity