Ryr3 Gene Summary [Rat]
Enables ryanodine-sensitive calcium-release channel activity. Involved in negative regulation of cytosolic calcium ion concentration and response to hypoxia. Located in cytoplasmic side of plasma membrane and perinuclear region of cytoplasm. Biomarker of pulmonary hypertension. Human ortholog(s) of this gene implicated in congenital myopathy 20 and hepatocellular carcinoma. Orthologous to human RYR3 (ryanodine receptor 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ryr3 |
| Official Name | ryanodine receptor 3 [Source:RGD Symbol;Acc:68952] |
| Ensembl ID | ENSRNOG00000006645 |
| Bio databases IDs | |
| Aliases | ryanodine receptor 3 |
| Synonyms | C230090H21, CMYO20, CMYP20, Ryanodine receptor 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ryr3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ryanodine-sensitive calcium-release channel
- SPRY domain
- RyR and IP3R Homology associated
- EF-hand domain pair
- Inositol 1,4,5-trisphosphate/ryanodine receptor
- RIH domain
- MIR domain
- RyR domain
- beta-trefoil_MIR
- Ryanodine Receptor TM 4-6
- ion channel
- calcium-release channel
Pathways
Biological processes and signaling networks where the Ryr3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- hypotension
- schizophrenia
- obesity
- colorectal cancer
- non-insulin-dependent diabetes mellitus
- developmental epileptic encephalopathy
- diabetes mellitus
- rotator cuff injury
- diabetic nephropathy
role in cell
- expression in
- degranulation
- mass
- long term synaptic depression
- long-term potentiation
- degeneration
- degeneration in
- mobilization in
- homeostasis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- microsomal fraction
- junctional membrane complex
- Cytoplasm
- perinuclear region
- cellular membrane
- sarcoplasmic reticulum
- Mitochondria
- triad junctions
- cytoplasmic face of plasma membrane
- myoplasm
- paraspeckle-like structures
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ryr3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- striated muscle contraction
- cellular calcium ion homeostasis
- protein homotetramerization
- release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
- cellular response to calcium ion
- cellular response to magnesium ion
- calcium ion transport
- calcium ion transmembrane transport
- release of sequestered calcium ion into cytosol
- cellular response to caffeine
- calcium-mediated signaling
- cellular response to ATP
Cellular Component
Where in the cell the gene product is active
- Z disc
- calcium channel complex
- sarcolemma
- smooth endoplasmic reticulum
- membrane
- sarcoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- calcium-release channel activity
- ryanodine-sensitive calcium-release channel activity
- calmodulin binding
- calcium-induced calcium release activity
- calcium ion binding