Cd8a Gene Summary [Rat]
Enables protein kinase binding activity. Involved in response to methamphetamine hydrochloride. Located in cell surface. Biomarker of amphetamine abuse and brain infarction. Human ortholog(s) of this gene implicated in immunodeficiency 116. Orthologous to human CD8A (CD8 subunit alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cd8a |
| Official Name | CD8a molecule [Source:RGD Symbol;Acc:2316] |
| Ensembl ID | ENSRNOG00000007178 |
| Bio databases IDs | |
| Aliases | CD8a molecule |
| Synonyms | CD8, CD8alpha, CD8 subunit alpha, CD8 subunit α, Cd8 α, IMD116, Leu2, Ly-2, Ly-35, Ly-B, Lyt-2, p32 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cd8a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- complementarity-determining region
- protein kinase binding
- Immunoglobulin V-Type
- immunoglobulin domain
- ectodomain
- lymphocyte-specific protein tyrosine kinase binding domain
- protein binding
- identical protein binding
- binding protein
- cytoplasmic domain
- dilysine motif
- signal sequence domain
- lumenal domain
- transmembrane domain
- Immunoglobulin like
- hinge domain
- cytosolic tail domain
- Immunoglobulin V-set domain
Pathways
Biological processes and signaling networks where the Cd8a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- obesity
- Waldenström macroglobulinemia
- splenomegaly
- colorectal cancer
- adamantinomatous craniopharyngioma
- head and neck squamous cell cancer
- familial CD8 deficiency
- diabetic nephropathy
role in cell
- proliferation
- apoptosis
- production in
- activation in
- disruption
- quantity
- survival
- activation
- number
- stimulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-insoluble fractions
- cell surface
- cellular membrane
- Golgi Apparatus
- plasma membrane extracellular face
- membrane rafts
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cd8a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- T cell mediated immunity
- immune response
- cytotoxic T cell differentiation
- T cell activation
- adaptive immune response
- transmembrane receptor protein tyrosine kinase signaling pathway
- antigen processing and presentation
- cell surface receptor signaling pathway
- T cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- T cell receptor complex
- receptor complex
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- coreceptor activity
- MHC class I protein complex binding
- protein binding
- MHC class I protein binding