Capn3 Gene Summary [Rat]
Enables several functions, including calcium-dependent cysteine-type endopeptidase activity; enzyme binding activity; and titin binding activity. Involved in several processes, including response to calcium ion; response to muscle activity; and sodium-dependent self proteolysis. Located in T-tubule and Z disc. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in autosomal dominant limb-girdle muscular dystrophy; autosomal recessive limb-girdle muscular dystrophy type 2A; and muscular dystrophy. Orthologous to human CAPN3 (calpain 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Capn3 |
| Official Name | calpain 3 [Source:RGD Symbol;Acc:2269] |
| Ensembl ID | ENSRNOG00000008609 |
| Bio databases IDs | |
| Aliases | calpain 3 |
| Synonyms | Calpain-3, CANP3, CANPL3, Capa-3, LGMD2, LGMD2A, LGMDD4, LGMDR1, Lp82, Lp84, Lp85, M calpain, nCL-1, p94 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Capn3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptidase
- enzyme
- identical protein binding
- The penta-EF hand (PEF) family
- C2-like domain
- EF-hand domain
- cysteine-type peptidase
- Unstructured region on Calpain-3
- cytoskeletal protein binding
- EF hand
- EF-hand, calcium binding motif
- calpain
- EF-hand domain pair
- calmodulin binding domain
- metal ion binding
- enzyme binding
- calcium ion binding
- EFh
- enzyme regulator activity
- protein binding
- receptor binding
- CysPc
- Calpain family cysteine protease
- structural constituent of muscle
- active site
- Calpain_III
Pathways
Biological processes and signaling networks where the Capn3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Amyloid Processing
- Amyotrophic Lateral Sclerosis Signaling
- Apoptosis Signaling
- Cellular Effects of Sildenafil (Viagra)
- Huntington's Disease Signaling
- Integrin Signaling
- Mitochondrial Dysfunction
- nNOS Signaling in Neurons
- nNOS Signaling in Skeletal Muscle Cells
- Regulation of Cellular Mechanics by Calpain Protease
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- limb-girdle muscular dystrophy type 2
- limb-girdle muscular dystrophy type 2A
- autosomal dominant limb-girdle muscular dystrophy type 4
- idiopathic eosinophilic myositis
- diabetic nephropathy
- eosinophilic myositis
- Parkinson disease
- autosomal dominant limb-girdle muscular dystrophy
- ischemic stroke
role in cell
- expression in
- apoptosis
- production in
- formation in
- cell viability
- cell death
- differentiation
- number
- assembly
- cell proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Plasma Membrane
- costameres
- cytosol
- nucleoli
- myofibrils
- I band
- m-bands
- Z line
- myotendinous junctions
- transverse tubules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Capn3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle cell homeostasis
- regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of proteolysis
- positive regulation of NF-kappaB transcription factor activity
- self proteolysis
- cellular response to salt stress
- cellular response to calcium ion
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- positive regulation of satellite cell activation involved in skeletal muscle regeneration
- regulation of catalytic activity
- apoptotic process
- muscle structure development
- negative regulation of protein sumoylation
- response to muscle activity
- macromolecular complex assembly
- protein catabolic process
- sarcomere organization
- positive regulation of release of sequestered calcium ion into cytosol
- myofibril assembly
- muscle organ development
- protein destabilization
- regulation of myoblast differentiation
- negative regulation of apoptotic process
- response to calcium ion
- proteolysis
- protein localization in membrane
- G1 to G0 transition involved in cell differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- Z disc
- T-tubule
- cytoplasm
- cytosol
- macromolecular complex
- nucleolus
- plasma membrane
- myofibril
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural constituent of muscle
- catalytic activity
- calcium ion binding
- titin binding
- ligase regulator activity
- cysteine-type peptidase activity
- peptidase activity
- calcium-dependent cysteine-type endopeptidase activity
- sodium ion binding
- binding, bridging