Myl1 Gene Summary [Rat]
Predicted to be a structural constituent of muscle. Involved in cardiac muscle contraction. Located in contractile muscle fiber. Human ortholog(s) of this gene implicated in congenital myopathy 14. Orthologous to human MYL1 (myosin light chain 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Myl1 |
| Official Name | myosin, light chain 1 [Source:RGD Symbol;Acc:1598796] |
| Ensembl ID | ENSRNOG00000013262 |
| Bio databases IDs | |
| Aliases | myosin, light chain 1 |
| Synonyms | AI325107, CMYO14, CMYP14, D12Mgi45, FAST SKELETAL MUSCLE MYOSIN LIGHT CHAIN, Lc1, Mcl3, MLC-1, MLC1/3, MLC1F, MLC3, MLC3-f, MLC-f, Mylf, MYOFTA, Myosin alkali light chain, myosin light chain 1, myosin, light chain 1, Myosin light chain alkali fast skeletal muscle, MYOSIN LIGHT CHAIN I, myosin, light polypeptide 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Myl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand domain
- structural constituent of muscle
- EF-hand domain pair
- EFh
Pathways
Biological processes and signaling networks where the Myl1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Agranulocyte Adhesion and Diapedesis
- Apelin Cardiomyocyte Signaling Pathway
- Axonal Guidance Signaling
- Calcium Signaling
- Cardiac Hypertrophy Signaling
- Cdc42 Signaling
- Cellular Effects of Sildenafil (Viagra)
- CXCR4 Signaling
- Ephrin A Signaling
- Estrogen Receptor Signaling
- G-Protein Coupled Receptor Signaling
- Gα12/13 Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- ILK Signaling
- PAK Signaling
- Phagosome Formation
- Regulation of Actin-based Motility by Rho
- RhoA Signaling
- RhoGDI Signaling
- Signaling by Rho Family GTPases
- Thrombin Signaling
- Tight Junction Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- myofibrils
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Myl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle contraction
- muscle filament sliding
Cellular Component
Where in the cell the gene product is active
- contractile fiber
- muscle myosin complex
- myosin II complex
- cytosol
- sarcomere
- myofibril
Molecular Function
What the gene product does at the molecular level
- structural constituent of muscle
- calcium ion binding