Dixdc1 Gene Summary [Rat]
Enables mitogen-activated protein kinase kinase kinase binding activity. Involved in cerebellar cortex development; positive regulation of JNK cascade; and positive regulation of axonogenesis. Located in axon terminus and neuronal cell body. Part of protein-containing complex. Orthologous to human DIXDC1 (DIX domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dixdc1 |
| Official Name | DIX domain containing 1 [Source:RGD Symbol;Acc:1309902] |
| Ensembl ID | ENSRNOG00000010260 |
| Bio databases IDs | |
| Aliases | DIX domain containing 1 |
| Synonyms | 4930563F16RIK, CCD1, Ccd1Aalpha1L, Ccd1Abeta1L, Ccd1BalphaL, Ccd1BbetaL, Ccd1CL, DIX domain containing 1, KIAA1735, LOC330938, mKIAA1735 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dixdc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- gamma-tubulin binding
- DIX domain
- Calponin homology domain
- protein kinase binding
- Growth-arrest specific micro-tubule binding
- calponin homology (CH) domain superfamily
- coiled-coil domain
- protein domain specific binding
- leucine zipper domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gait disturbance
- breast carcinoma
- endometrial cancer
- survival
- obesity
- progression free survival
role in cell
- formation
- activation in
- growth
- expression in
- invasion by
- differentiation
- organization
- tubulation by
- formation in
- length
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- postsynaptic region
- cytosol
- perikaryon
- axons
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dixdc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of microtubule cytoskeleton organization
- regulation of actin cytoskeleton organization
- forebrain ventricular zone progenitor cell division
- negative regulation of neuron differentiation
- canonical Wnt receptor signaling pathway
- cerebral cortex radially oriented cell migration
- positive regulation of Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- focal adhesion
- stress fiber
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- protein binding
- actin binding
- gamma-tubulin binding