Creb3l2 Gene Summary [Rat]

This gene encodes a member of the oasis bZIP transcription factor family. Members of this family can dimerize but form homodimers only. The encoded protein is a transcriptional activator. Translocations between this gene on chromosome 7 and the gene fused in sarcoma on chromosome 16 can be found in some tumors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Details

Type
Protein Coding
Official Symbol
Creb3l2
Official Name
cAMP responsive element binding protein 3-like 2 [Source:RGD Symbol;Acc:1306040]
Ensembl ID
ENSRNOG00000012826
Bio databases IDs NCBI: 362339 Ensembl: ENSRNOG00000012826
Aliases cAMP responsive element binding protein 3-like 2
Synonyms BBF2H7, C530025K05RIK, cAMP responsive element binding protein 3-like 2, DKFZp586F2423, LOC102552017, Ra69, SCIRR69
Species
Rat, Rattus norvegicus
OrthologiesHumanMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Creb3l2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding
  • transcription regulator
  • double-stranded DNA binding
  • nucleic acid binding
  • sequence-specific DNA binding
  • bZIP
  • basic region leucin zipper

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • non-insulin-dependent diabetes mellitus
  • refractive error
  • COVID-19
  • ulcerative colitis
  • chondrodysplasia
  • ischemic stroke
regulated by
  • GABA
  • thapsigargin
  • TCF7L2
  • tunicamycin
  • MR-409
  • natural killer cells
  • lipopolysaccharide
  • SOX9
  • beta-estradiol
  • dihydrotestosterone
regulates
  • COL2A1
  • MX1
  • DNA promoter
  • DNA endogenous promoter
  • MCL1
  • RNA polymerase II
  • Collagen type XI
  • hedgehog
  • mannosidase 2
  • EVX1
role in cell
  • expression in
  • migration
  • proliferation
  • signaling in
  • cell death
  • differentiation
  • apoptosis
  • size
  • number
  • development

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • Cytoplasm
  • Endoplasmic Reticulum
  • cytosol
  • reticular perinuclear compartment
  • endoplasmic reticulum membrane
  • Golgi membrane
  • nucleoplasm
  • chromatin

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the rat Creb3l2 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • ER to Golgi vesicle-mediated transport
  • positive regulation of transcription, DNA-dependent
  • chondrocyte differentiation
  • positive regulation of transcription from RNA polymerase II promoter
  • response to unfolded protein
  • response to endoplasmic reticulum stress
  • regulation of transcription from RNA polymerase II promoter
  • cartilage development

Cellular Component

Where in the cell the gene product is active
  • endoplasmic reticulum membrane
  • nucleus
  • endoplasmic reticulum
  • chromatin
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • cAMP response element binding
  • transcription regulatory region sequence-specific DNA binding
  • RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
  • sequence-specific DNA binding RNA polymerase II transcription factor activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.