Adcy7 Gene Summary [Rat]
Enables adenylate cyclase activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; cAMP biosynthetic process; and maternal process involved in female pregnancy. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human ADCY7 (adenylate cyclase 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adcy7 |
| Official Name | adenylate cyclase 7 [Source:RGD Symbol;Acc:619966] |
| Ensembl ID | ENSRNOG00000014776 |
| Bio databases IDs | |
| Aliases | adenylate cyclase 7 |
| Synonyms | AA407758, AC7, adenylate cyclase 7, KIAA0037 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Adcy7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- adenylate cyclase
- Class III nucleotidyl cyclases
- enzyme
- Adenylyl- / guanylyl cyclase, catalytic domain
- Adenylate cyclase, conserved domain
Pathways
Biological processes and signaling networks where the Adcy7 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Apelin Adipocyte Signaling Pathway
- Apelin Endothelial Signaling Pathway
- Cardiac β-adrenergic Signaling
- CDK5 Signaling
- Cellular Effects of Sildenafil (Viagra)
- Corticotropin Releasing Hormone Signaling
- CXCR4 Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Dopamine Receptor Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Endocannabinoid Developing Neuron Pathway
- Endothelin-1 Signaling
- eNOS Signaling
- Gustation Pathway
- Hepatic Cholestasis
- IL-1 Signaling
- Leptin Signaling in Obesity
- Melanocyte Development and Pigmentation Signaling
- P2Y Purinergic Receptor Signaling Pathway
- PPARα/RXRα Activation
- Protein Kinase A Signaling
- Renin-Angiotensin Signaling
- Thrombin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- schizophrenia
- hypothyroidism
- autoimmune disease
- Huntington disease
- autoimmune thyroid disease
- androgenic alopecia
- inflammatory bowel disease
- ulcerative colitis
- aortic valve calcification
role in cell
- generation
- response by
- production in
- synthesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Adcy7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to ethanol
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- cAMP biosynthetic process
- cellular response to lithium ion
- maternal process involved in female pregnancy
- negative regulation of cytokine production involved in inflammatory response
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- regulation of adaptive immune response
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- metal ion binding
- adenylate cyclase activity