Il11 Gene Summary [Rat]
Predicted to enable cytokine activity; growth factor activity; and interleukin-11 receptor binding activity. Predicted to be involved in interleukin-11-mediated signaling pathway; positive regulation of MAPK cascade; and positive regulation of cell population proliferation. Predicted to act upstream of or within negative regulation of hormone secretion and positive regulation of macromolecule metabolic process. Predicted to be active in cytoplasm and extracellular space. Orthologous to human IL11 (interleukin 11). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il11 |
| Official Name | interleukin 11 [Source:RGD Symbol;Acc:621475] |
| Ensembl ID | ENSRNOG00000017386 |
| Bio databases IDs | |
| Aliases | interleukin 11 |
| Synonyms | AGIF, interleukin 11, LOC100503163 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Il11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- receptor binding domain
- interleukin-11 receptor binding
- protein binding
- cytokine
- Interleukin 11
- growth factor
Pathways
Biological processes and signaling networks where the Il11 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Erythropoietin Signaling
- Hematopoiesis from Pluripotent Stem Cells
- Hepatic Cholestasis
- HMGB1 Signaling
- IL-17 Signaling
- RAR Activation
- Role of IL-17F in Allergic Inflammatory Airway Diseases
- Role of JAK family kinases in IL-6-type Cytokine Signaling
- Role of NFAT in Cardiac Hypertrophy
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- osteoarthritis
- diarrhea
- epithelial cancer
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
- cancer
- epithelial neoplasia
role in cell
- colony formation
- invasion by
- accumulation
- expression in
- phosphorylation in
- binding in
- growth
- migration
- proliferation
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Il11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- interleukin-11-mediated signaling pathway
- B cell differentiation
- positive regulation of cell proliferation
- fat cell differentiation
- positive regulation of MAPK cascade
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of hormone secretion
- megakaryocyte differentiation
- negative regulation of endothelial cell apoptotic process
- positive regulation of peptidyl-tyrosine phosphorylation
- positive regulation of peptidyl-serine phosphorylation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- interleukin-11 receptor binding
- cytokine activity