C6 Gene Summary [Rat]
Involved in positive regulation of apoptotic process. Located in extracellular space. Used to study end stage renal disease; glomerulonephritis; and proteinuria. Human ortholog(s) of this gene implicated in complement component 6 deficiency. Orthologous to human C6 (complement C6). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | C6 |
| Official Name | complement C6 [Source:RGD Symbol;Acc:2238] |
| Ensembl ID | ENSRNOG00000024115 |
| Bio databases IDs | |
| Aliases | complement C6 |
| Synonyms | complement C6, complement component 6 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat C6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CCP
- Thrombospondin type 1 repeats
- Thrombospondin type 1 domain
- factor I module
- membrane-attack complex / perforin
- MAC/Perforin domain
- factor I membrane attack complex
- LDLa
- Sushi repeat (SCR repeat)
- protein binding
- Spondin-like TSP1 domain
- SUSHI repeat
Pathways
Biological processes and signaling networks where the C6 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- heart disease
- complement component C6 deficiency
- hepatocellular carcinoma
- hepatitis B virus-related hepatocellular carcinoma
- liver cancer
- epithelial cancer
- choroidal neovascularization
- COVID-19
- experimental autoimmune encephalomyelitis
- Wallerian degeneration
role in cell
- production in
- apoptosis
- cellular infiltration by
- accumulation
- phosphorylation in
- activation
- number
- loss
- quantity
- phagocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat C6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- complement activation
- in utero embryonic development
- complement activation, classical pathway
- innate immune response
- killing of cells of other organism
- positive regulation of immune response
Cellular Component
Where in the cell the gene product is active
- membrane attack complex
- extracellular space
- extracellular vesicular exosome
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding